Direct Synthesis of Triazaaryl Phosphine Sulfides from White Phosphorus
Yu Chen, Yu-Zhong Yang, Xinlei Huangfu, Junnian Wei, Peifeng Mei*, Yulong Li*, and Wen-Xiong Zhang*
J. Org. Chem. 2026, 91, 2345–2352.
https://doi.org/10.1021/acs.joc.5c02425
A chlorine-free reaction was developed to synthesize triazaaryl phosphine sulfides and their analogues from white phosphorus (P4). Mediated by diphenyl disulfide/diselenide and sodium hydride, P-N bond was formed directly from P4 with N-heteroaromatic substrates. This method features one-pot process, mild conditions and good substrate tolerance. A series of triazaaryl phosphine sulfides and their analogues was prepared with mild to excellent yields (58%-98%). In addition, the disulfide/diselenide media could be recycled.
