Xinyuan Fan

PhD, Research Associate Professor

Email: xinyuanfan@pku.edu.cn;  Tel: 010-62754127;  

EDUCATION AND EXPERIENCE

2019 – present, Research Associate Professor, Peking University 

2017 – 2019, Associate professor, Nanjing Tech University 

2014 – 2017, Postdoctoral fellow, Peking University 

2013 – University of Pennsylvania, Visiting scholar, Organic chemistry.

2010 – 2014, ICIQ - Institute of Chemical Research of Catalonia (Spain), Ph.D, Organic chemistry   

2003 – 2010, Lanzhou University, BS & MS, Biotechnology and Biochemistry

 

RESEARCH INTERESTS
Chemical biology, Bioorthogonal photocatalysis, Bioorthogonal chemistry, Photocatalytic chemistry

AWARDS

National Science Fund for Excellent Young Scholars of China 

NG Teng Fong/ Sino Scholarship for Outstanding Youth

Li Ge-Zhao Ning Youth Fund for Life Sciences

 

SELECTED PUBLICATIONS

1) Bi, Y.#; Yu, L.#; Deng, Q.#; Kong, L.; Guo, F.; Zhang, Y.; Wang, R.; Chen, P.*; Liu, J.*; Fan, X.*, “Photocatalytic Proximity Labeling-Enabled Subcellular-Resolved RNA Profiling and Synchronous Multi-omics Investigation.” Nat. Chem. 2025, 17 (12), 1871-1882. (CAT-seq and CAT-ortho technologies)

Bi, Y.; Fan, X.*, “Simultaneous subcellular RNA–protein profiling with photocatalytic labelling.” Nat. Chem. 2025, 17 (12), 1817-1818. (Research Briefing of CAT-ortho)

2) Zhou, N.#; Zhang, Y.#; Chen, P.*; Fan, X.*, “Time-Resolved Photocatalytic Proximity Labeling Uncovers ER Proteome Dynamics Underlying UPR to Apoptosis Transition.” PNAS 2025, 122, e2503115122. (CAT-ER technology)

3) Lou, Z.#; Zhang, Y.#; Liang, X.; Cao, M.; Ma, Y.; Chen, P.*; Fan, X.*, “Deep-Red and Ultrafast Photocatalytic Proximity Labeling Empowered in situ Dissection of Tumor-Immune Interactions in Primary Tissues.” J. Am. Chem. Soc. 2025, 9716-9726. (CAT-Tissue technology)

4) Zhang, Y.#; Liu, Z.#; Zhou, N.#; Guo, F.; Guo, H.; Chen, X.; Chen, P.*; Fan, X.*, “In situ Lysosomal Proteomics Enabled by Bioorthogonal Photocatalytic Proximity Labeling.” Nat. Catal. 2025, 162-177 (CAT-Lyso technology)

5) Liu, Z.#; Guo, F.#; Zhu, Y.; Qin, S.; Hou, Y.; Lin, F.; Guo, H.; Chen, P.*; Fan, X.*, “Bioorthogonal Photocatalytic Proximity Labeling in Primary Living Samples.” Nat. Commun. 2024, 15 (1), 2712. (CAT-S technology)

6) Zhang, Y.; Liu, S.; Guo, F.; Qin, S.; Zhou, N.; Fan, X.*; Chen, P.*, Bioorthogonal photocatalytic quinone methide decaging for cell-cell interaction labeling. J. Am. Chem. Soc. 2024, 146, 15186-15197. (CAT-Cell technology)

7) Liang, X.#; Qian, S.#; Lou, Z.; Hu, R.; Hou, Y.; Chen, P.*; Fan, X.*, Near Infrared Light-Triggered Photocatalytic Decaging for Remote-Controlled Spatiotemporal Activation in Living Mice. Angew. Chem. Int. Ed. 2023, e202310920. (CAT-NIR technology)

8) Liu, Z.; Xie, X.; Huang, Z.; Lin, F.; Liu, S.; Chen, Z.; Qin, S.; Fan, X.*; Chen, P.*, Spatially resolved cell tagging and surfaceome labeling via targeted photocatalytic decaging. Chem 2022, 8, 2179–2191. (CAT-Ex technology)

9) Luo, H.#; Tang, W.#; Liu, H.; Zeng, X.; Ngai, W. S. C.; Gao, R.; Li, H.; Li, R.; Zheng, H.; Guo, J.; Qin, F.; Wang, G.; Li, K.; Fan, X.*; Zou, P.*; Chen, P.*, Photocatalytic Chemical Crosslinking for Profiling RNA–Protein Interactions in Living Cells. Angew. Chem. Int. Ed. 2022, 61 (27), e202202008. (CAX technology)

10) Huang, Z.#; Liu, Z.#; Xie, X.; Zeng, R.; Chen, Z.; Kong, L.; Fan, X.*; Chen, P.*, Bioorthogonal Photocatalytic Decaging-Enabled Mitochondrial Proteomics. J. Am. Chem. Soc. 2021, 143 (44), 18714-18720. (CAT-Prox technology)


For full list of publications, please see: ‪Xinyuan Fan - ‪Google Scholar

https://scholar.google.com/citations?hl=en&user=W2AGqkQAAAAJ&view_op=list_works&sortby=pubdate